This was an experimental study delivered online of emotional bias training (EBT) in a sample of participants (n = 212) currently taking selective serotonin re-uptake inhibitors (SSRIs) to manage anxiety and/or depression, recruited via Prolific (prolific.co). The study aimed to investigate the effect of active EBT on a range of mental health and functional outcomes, with the primary outcome measure being self-reported quality of life enjoyment and satisfaction. Participants completed 4 sessions of either sham or active EBT within 10 days. Outcome measures were assessed at baseline (session 1), immediately post-training (end of session 4) and at a two-week follow-up (session 5). The protocol was pre-registered on the Open Science Framework (OSF) (osf.io/5z3wr). Ethics approval was obtained from the Faculty of Science Research Ethics Committee at the University of Bristol (reference: 55441) The deposit includes the following files: Emotion_Bias_Medicated_DataDictionary_20200517 Emotion_Bias_Medicated_DataSheet_20200517 Emotion_Bias_Medicated_RScript_20210125 Emotion_Bias_Medicated_InformationSheet_20210128 Emotion_Bias_Medicated_Consent_20210128 Emotion_Bias_Medicated_Protocol_20210128 The summary data sheet and data dictionary are in CSV format, and the R Script is in TXT format. These can be opened in a number of software packages. The R analysis script was written in RStudio (R version 3.6.2). R and RStudio can be downloaded from www.r-project.org and www.rstudio.com, respectively. References: Suddell, S., Müller-Glodde, M., Lumsden, J. A., Looi, C. Y., Granger, K., Barnett, J. H., … Penton-Voak, I. (2020). Emotional bias training as a treatment for anxiety and depression: Evidence from experimental medicine studies in healthy and medicated samples. PsyArXiv, doi.org/10.31234/osf.io/xvkb2