dog osteoarthritis project

Osteoarthritis (OA) is very common cause of chronic pain in dogs. We currently assume that all dogs with OA suffer similarly from pain and show similar altered sensitivity to sensory stimuli such as heat and pressure. However, in people suffering from OA, different types of pain associated with different sensory sensitivities are recognized, and these distinct pain patterns are likely associated with different underlying changes in the sensory nervous system. Furthermore, these distinct pain patterns are likely to predict response to different analgesic drugs. We predict, given the similarity between the disease of OA in dogs and people, that we will be able to identify similar distinct pain patterns in dogs suffering from osteoarthritis.
We will study pet dogs with OA, recruited through liaison with veterinary surgeons. We will use a simple, validated experimental paradigm to determine underlying pain mechanisms in individual dogs and subsequently map the individual pain pattern or pain phenotype to allow us to link pain mechanism with clinical pain expression. These data support the publication "Alfaxalone anaesthesia facilitates electrophysiological recordings of nociceptive withdrawal reflexes in dogs (Canis familiaris" [PLoS One]

Creator(s) Toby Knowles, Helen Whay, Joanna Murrell, James Hunt, Helen Jenkins, Megan Goff, Michael Mendl
Funder Biotechnology and Biological Sciences Research Council
Publication date 22 Jan 2016
Language eng
Publisher University of Bristol
Licence Non-Commercial Government License for public sector information
DOI 10.5523/bris.oiz5chav11491k3x9l92zlr6w
Complete download (zip) http://data.bris.ac.uk/datasets/oiz5chav11491k3x9l92zlr6w/oiz5chav11491k3x9l92zlr6w.zip
Citation Toby Knowles, Helen Whay, Joanna Murrell, James Hunt, Helen Jenkins, Megan Goff, Michael Mendl (2016): dog osteoarthritis project. https://doi.org/10.5523/bris.oiz5chav11491k3x9l92zlr6w
Total size 442.8 KiB

Data Resources